I am partial to revolvers for most applications
And I think they are much better for all 'casual' uses.
Autos are fine for most others, but they demand a higher level of attention all around.
If you wanted to, you could load a Ruger SP101, put in in a pocket holster, then 'never' take it out unless you needed it, and you could still depend on it to work.
I wouldn't try that with any auto, including the Colt Defender, notwithstanding its reputation for reliability.
HTH 
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Complete thread:
- For conversation sake: Colt Defender vs Ruger SP101 3 inch -
MR,
2013-04-20, 14:02
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- One in each pocket :-) - mcassill, 2013-04-20, 14:13
- I am partial to revolvers for most applications - FOG, 2013-04-20, 14:40
- 20 years later, I'm still lukewarm on my SP101 - BC, 2013-04-20, 15:32