I'd say use whatever is comfortable to your...

by Sarge , Central Misery, Tuesday, November 05, 2013, 12:48 (4041 days ago) @ Mark Stevenson

anatomy; just use it all the time so it burns into your muscle memory.

I stated shooting a lot one handed a few years ago because I think it's an excellent marksmanship practice, and a number of 'under stress' shootings I'm familiar with were successfully resolved with one hand.

I think because the speed, angle and proximity of the attack it is often impossible to get both hands on the gun or orient the entire body to allow engaging a threat with both hands on it. My own limited experience with this bears this out and it's reassuring to know you are going to hit despite this supposed handicap.