Living off the land
I lived in Ecuador for some years and spent time in the jungle with the tribes. While there I hunted with the men for food and used a Colt Huntsman 22 autopistol. I had a long time to think about the perfect handgun for living off the land in places where no help was available except what you had on your hip. When I returned stateside I bought my perfect pistol and this is it. A stainless Smith and Wesson Kit-Gun (Model 63) and the grips are by Herrett. A real shame these things are no longer available.
If you can hold it steady enough, this pistol will produce groups as small as the larger and heaviers K-22. Not a bear gun, but I have killed 20 pound monkeys with the Huntsman, plus all kinds of birds. I once killed a tapir with a head shot. They guys had speared it and it was making quite a rukus with them.